Autosomal dominant PKD

Autosomal dominant PKD (ADPKD) is the most common form of PKD. It accounts for about 90% of all PKD cases. Autosomal dominant means that if one parent has the disease there is a 50% chance that the disease will pass to a child. Both males and females are equally affected.

ADPKD used to be called adult polycystic kidney disease. It is often diagnosed in adulthood. Usually, at least one parent must have the disease for a child to inherit it. In 10% of cases, there may be no family history of PKD. These cases are new mutations in a family. In very few cases, this type of PKD happens suddenly after conception. Parents would not be at increased risk to have more children with PKD. But people with PKD have a 50/50 chance of passing the gene on to their children.

Symptoms often start between age 30 and 40. But they can begin in childhood. They may include:

• Belly pain

• Detectable belly mass

• Pale color to skin

• Easy bruising

• High blood pressure

• Kidney stones

• Aneurysms (bulging of the walls of blood vessels) in the brain

• Diverticulosis (pouches in the intestines)

• Urinary tract infections

• Hematuria (blood in the urine)

• Liver and pancreatic cysts

• Abnormal heart valves

ADPKD may happen with other conditions, such as:

• Tuberous sclerosis (a genetic syndrome involving seizures, intellectual disability, benign tumors, and skin lesions)

• Liver disease

• Severe eye problems 

The symptoms of ADPKD sometimes look like other health problems. Always see your healthcare provider for a diagnosis.

Diagnosis of ADPKD may include the use of imaging tests to detect cysts on the kidney and other organs and a review of the family history. There are 3 different dominant genes that have been identified. They further subdivide this type into PKD1, PKD2, and PKD3.

A healthcare provider will create a treatment plan after careful consideration of symptoms and medical history. Treatment may include:

• Pain medicine

• Surgery to shrink cysts and ease pain

• Treatment for high blood pressure

• Treatment for urinary tract infections

• Dialysis

• Kidney transplant

Autosomal recessive PKD

Autosomal recessive PKD (ARPKD) is a rare form of PKD. It is thought to be caused by a particular genetic flaw. This is different from the genetic flaw that causes ADPKD. Parents who do not have the disease can have a child with the disease if both parents carry the abnormal gene and both pass the gene to their child. Carrier parents have a 25% chance with each pregnancy to have a child with this type of PKD. Males and females are equally affected.

ARPKD is sometimes found prenatally (before birth) using a fetal ultrasound. Symptoms of can start before birth. In most cases, the earlier the onset, the more severe the outcome.

Children born with ARPKD may develop kidney failure within a few years. They often have:

• High blood pressure

• Urinary tract infections

• Frequent urination

The disease also usually affects the liver, spleen, and pancreas. This results in low blood cell counts, varicose veins, and hemorrhoids.

The symptoms of ARPKD may look like other health problems. Always talk with a healthcare provider for a diagnosis.

Diagnosis often includes ultrasound imaging of the fetus or newborn to reveal cysts in the kidneys. An ultrasound exam of kidneys of relatives may also be helpful.

A healthcare provider will figure out a treatment plan for ARPKD after careful consideration of the child's symptoms and medical history. Treatment may include:

• Treatment for high blood pressure

• Treatment for urinary tract infections

• Hormonal therapy

• Dialysis

• Kidney transplant