All About Cholesterol-Lowering Medicines

Healthy lifestyle changes alone may be enough to help some people reach healthy cholesterol levels. Other people will need to take a cholesterol-lowering medicine. If you need medicine e, talk with your healthcare provider and work together to find the best option for you.

There are 7 main types of medicine:

• Statins. These include atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, and simvastatin. These medicines lower LDL ("bad") cholesterol. They typically reduce LDL by about one-third. They can also help raise HDL ("good") cholesterol and lower triglycerides (other blood fats). Statins slow the body's production of cholesterol. They also increase the liver's ability to remove LDL from the blood. In research on people who already had heart disease, statins greatly reduced heart attacks and heart disease deaths. They may also prevent first heart attacks in people who are at high risk for heart disease.

• Bile acid sequestrants. These include cholestyramine, colesevelam, and colestipol. These medicines also lower LDL, although somewhat less than statins. These medicines bind with bile acids in the intestines and force them to leave the body in the stool instead of being absorbed into the blood stream. The liver needs cholesterol to make bile acids and important growth and stress hormones. So as more bile is lost, more cholesterol from your body is used up to make more bile. 

• Nicotinic acid (niacin). This B vitamin increases HDL and lowers LDL and triglycerides when taken at levels higher than needed in the diet. Nicotinic acid is sold as both a prescription medicine and a dietary supplement. But only the prescription form should be used to lower cholesterol. Some people don't tolerate the high doses because these medicines cause flushing or a burning or itching sensation.

• Fibrates. These include gemfibrozil and fenofibrate. These drugs lower triglycerides. They may also lead to modest improvements in LDL and HDL levels.

• Selective cholesterol absorption inhibitors. An example is ezetimibe. This medicine lowers cholesterol by reducing the amount of cholesterol absorbed by the intestines. Ezetimibe, bile acid sequestrants, and nicotinic acid are sometimes combined with a statin to help people reach their LDL cholesterol-lowering levels.

• PCSK9 inhibitors. These include alirocumab and evolocumab. These newest medicines are injected in the skin and contain antibodies that bind to an important enzyme involved in the removal of LDL from the bloodstream. These medicines may lower LDL levels by almost half and can reduce the risk of heart attack.

• Omega 3 fatty acid ethyl esters. This includes fish oils. This type of medicine is used along with diet and lifestyle to help people lower their triglycerides when the levels are above 500 mg/dL. This type of cholesterol medicine should not be used by anyone with a severe allergy to fish or shellfish due to the risk of a severe reaction.